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Medical News Today: 02-26-2005

New binding target for oncogenic viral protein
The DNA tumor virus simian virus 40 produces the Large T antigen which inactivates two of the cell's most important cancer-preventing proteins, p53 and pRb... click link for more info.

Researchers find a mutation in LRRK2 gene causes Parkinson's disease in several North American and European families
Neuroscientists at Mayo Clinic in Jacksonville, Fla... click link for more info.

Cameroon Health Ministry Agrees To Allow Follow-Up in Viread Trial; FHI To Help Participants Infected During Study Access Treatmen
Cameroon's Ministry of Health over the past few days has agreed to allow the follow-up of participants currently enrolled in a clinical trial that is testing the antiretroviral drug Viread, known generically as tenofovir, to determine if it can reduce the risk of HIV infection, the... click link for more info.

San Francisco Board of Supervisors Votes To Allow Pharmacies To Sell Syringes Without Prescriptions
The San Francisco Board of Supervisors on Tuesday unanimously approved an ordinance that would allow city... click link for more info.

Inadequate Health Infrastructures in Africa Limiting Number of Patients Receiving HIV/AIDS Care, Boston Globe
More than 20 sub-Saharan African countries are limiting the number of new patients receiving HIV/AIDS care because of insufficient health infrastructures and a shortage of health care workers, problems that pose a "major new obstacle" for expanding treatment programs in the region, the... click link for more info.

Officials Discuss Increasing HIV/AIDS Incidence Among Women in Middle East, North Africa, Call for Action
More needs to be done to protect women in the Middle East and North Africa from HIV/AIDS, according to health officials meeting in Amman, Jordan, at a three-day conference sponsored by... click link for more info.

USA Today Examines India's HIV/AIDS Epidemic, Responses From Government, Nongovernmental Organizations
... click link for more info.

UNICEF Director Calls on China To Expand HIV/AIDS Prevention, Treatment Efforts
China needs to expand its response to the country's burgeoning HIV/AIDS epidemic and focus more on HIV prevention and treatment efforts... click link for more info.

Uganda's Decline in HIV/AIDS Prevalence Attributed to Increased Condom Use, Early Death From AIDS, Study Says
Increased condom use and premature deaths from AIDS-related diseases might be playing more of a role in declining HIV prevalence in Uganda than abstinence and fidelity, according to a study presented Wednesday at the... click link for more info.

Poor prenatal nutrition permanently damages function of insulin-producing cells in the pancreas
Scientists at Joslin Diabetes Center have discovered one reason why infants with low birth weight have a high potential of developing type 2 diabetes later in life... click link for more info.

Comment on NHS Breast Screening Programme statistics
Leading cancer care charity Macmillan Cancer Relief commented on the news that over 11,000 cancers have been detected in the past year thanks to the NHS Breast Screening Programme... click link for more info.

Genetic amplification (NAAT) test detects HIV more effectively than standard tests in urban study
Adding a new HIV screening method, called nucleic acid amplification testing (NAAT), to standard HIV testing, researchers were able to uncover six percent more cases of HIV infection in urban STD and drug treatment clinics and HIV testing sites in Atlanta than with standard HIV antibody tests alone... click link for more info.

Patient knows best when it comes to ulcerative colitis, U-M study finds
People living with fatigue, abdominal discomfort and bloody diarrhea caused by the chronic inflammation of ulcerative colitis may no longer need to undergo frequent and uncomfortable endoscopies, a new study shows... click link for more info.

Elderly receiving inappropriate prescriptions from their doctor's office
A large review of data linked to over 175,000 older adults enrolled in HMOs indicates that potentially inappropriate medications are being prescribed in substantial numbers... click link for more info.

New NIST reference material reinforces fragile-x screens
A new Standard Reference Material from the National Institute of Standards and Technology (NIST) will help clinical genetics labs improve the accuracy of their diagnostic tests for the most common cause of hereditary mental retardation... click link for more info.

Infectious microorganism linked to kidney stones and other diseases
NASA researchers announce a potential cause of rapid kidney stone formation in astronauts on space travels... click link for more info.

Protecting drinking water supplies within buildings
Mention drinking water contamination and most people would suspect problems with the ground water or with a water treatment plant... click link for more info.

Adverse drug events in nursing homes are far more common than previously identified
Injuries from adverse drug events in the long-term care setting are more common than previously documented, and largely preventable, according to the findings of a study published today in The American Journal of Medicine... click link for more info.

Cellular porthole connects odors to brain
A cellular "porthole" known best for its role in the digestive system apparently has a major role in helping the brain sense odors, Johns Hopkins scientists report in the Feb... click link for more info.

Fox Chase Cancer Center scientists identify immune-system mutation
A team of Fox Chase Cancer Center scientists led by immunologist Dietmar J... click link for more info.

Salt Kills 150,000 a Year, Says CSPI Report
Too much salt in the diet is boosting Americans' blood pressure and is prematurely killing roughly 150,000 people each year, according to a new report issued today by the nonprofit Center for Science in the Public Interest (CSPI)... click link for more info.

History of broken bones overlooked when treating osteoporosis
Women who need treatment for osteoporosis--thinning of the bones--may not be receiving it because their history of fractures is not being considered by physicians, according to a study done in part at the University of Alberta... click link for more info.

New radio-frequency technique for knee injuries
The application of a new technique for injuries of the cruciate ligament in the knee, involving the use of bipolar radio-frequency plus heat, has proved to be 90% effective in cases and shortens the recovery time of the patient... click link for more info.

FDA Approves Astrazeneca's Atacand(R) (Candesartan Cilexetil) For The Treatment Of Heart Failure
Atacand is first ARB to receive approval for reducing both CV mortality and hospitalizations for heart failure - AstraZeneca today announced that the US Food and Drug Administration (FDA) has approved its angiotensin receptor blocker (ARB) ATACAND(r) (candesartan cilexetil) Tablets for the treatment of heart failure (NYHA class II-IV and ejection fraction ˜ 40%) to reduce the risk of death from cardiovascular causes and reduce hospitalizations for heart failure... click link for more info.

New imaging technologies can enhance orthopaedic outcomes
New imaging technologies are enabling doctors to not only diagnose a variety of orthopaedic and musculoskeletal conditions with more accuracy, but also to determine with unprecedented precision whether clinical recovery from bone, joint or tendon damage is actually complete and not simply a "placebo effect... click link for more info.

Dysentery uses 'sword and shield' to cause infection
Scientists have found that the bacterium that causes dysentery uses a 'sword and shield' approach to cause infection... click link for more info.

BMA Scotland doctors comment on below average pay rises
Doctors comment on below average pay rises - The British Medical Association commented on below-average* pay rises for doctors... click link for more info.

Study Examines Harm Reduction Among Injection Drug Users
Nearly half of injection drug users disposed of their used syringes safely, yet only 28 percent acquired their needles from safe sources, according to a study of injection drug users in Baltimore, Md... click link for more info.

Study documents initial differences in sexual transmission of HIV between males and females
A genetic analysis of viral RNA from 10 heterosexual couples, in which one partner has sexually transmitted HIV to the other, provides the first documentation of some differences in how the virus infects males and females... click link for more info.

NIH awards grant to explore causal relationship between epoetin dose and survival of hemodialysis patients
The National Institutes of Health, National Institute of Diabetes & Digestive & Kidney Diseases (NIDDK) has awarded a two-year grant to the Medical Technology and Practice Patterns Institute (MTPPI) in collaboration with Harvard School of Public Health (HSPH) to explore the causal relationship between epoetin dose and survival of hemodialysis patients receiving this therapy... click link for more info.

Inpatient smoking cessation counseling is associated with early differences in mortality
Giving up smoking after a heart attack has been clearly associated with improvements in long-term patient survival, but how soon after myocardial infarction does smoking cessation begin to have positive effects? A study published in the current issue of The American Journal of Medicine indicates in-hospital cessation counseling following heart attacks is associated with better short-term survival... click link for more info.

Commissioning guidance leaves GPs in the dark, says BMA, UK
With one month to go before the introduction of Practice Based Commissioning from April 2005, allowing GP practices to take over responsibilities and budgets for some local NHS services, the British Medical Association says the government has omitted essential key information from its Technical Guidance published today (23/02/2005)... click link for more info.

It's not all genetic: Common epigenetic problem doubles cancer risk in mice
In experiments with mice, a team of scientists from the United States, Sweden and Japan has discovered that having a double dose of one protein is sufficient to change the normal balance of cells within the lining of the colon, thereby doubling the risk that a cancer-causing genetic mutation will trigger a tumor there... click link for more info.

OHSU scientists develop MRI approach to improve breast cancer detection
Researchers at Oregon Health & Science University's Advanced Imaging Research Center (AIRC) are developing a new imaging method that may provide a clearer diagnosis of breast cancer... click link for more info.

Cartilage repair techniques shown to restore patient mobility and reduce pain
Two separate new studies presented at a major medical meeting provide objective scientific evidence that the two most commonly performed cartilage repair techniques are effective at restoring patient mobility and reducing pain... click link for more info.

Sexual banter in workplace may have its benefits
A little sexual banter in the workplace isn't necessarily a bad thing... click link for more info.

Schepens scientists regenerate optic nerve for the first time
For the first time, scientists have regenerated a damaged optic nerve -- from the eye to the brain... click link for more info.

Recent breakthroughs in common adult leukemia highlighted in New England Journal of Medicine
When the most common adult leukemia in the United States was last reviewed by the New England Journal of Medicine (NEJM) in 1995, it was seen through the eyes of theories that dated back to the 1960s... click link for more info.

CK2 protein sustains colon cancer cells by sabotaging ability to commit suicide
A protein called CK2 plays a deadly role in colorectal carcinoma by blocking the ability of these tumors to activate a natural self-destruct mechanism that would clear this cancer from the body... click link for more info.

Protein that promotes survival of stem cells might be key to poor leukemia prognosis
The complex and life-sustaining series of steps by which hematopoietic stem cells (HSC) give rise to all of the body's red and white blood cells and platelets has now been discovered to depend in large part on a single protein called Mcl-1... click link for more info.

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