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Eurekalert Medical and Health News: 11-19-2004

Study examines nature and prevalence of errors in patient care
A University of Pennsylvania School of Nursing study provides the first detailed description of the nature and prevalence of errors by hospital staff nurses. During a 28-day period, journals kept by 393 registered nurses revealed that 30 percent of the nurses reported at least one error and 33 percent reported at least one near-error. According to the researchers, the errors frequently stem from the complex and distracting nature of the hospital work environment.

Surgery without the scapel: U. Va. Health System marks fifteenth anniversary of Gamma knife
In 1989, when the University of Virginia Health System installed the first Gamma Knife neurosurgical instrument in Virginia, George H. W. Bush was president and the Berlin Wall was coming down. U.Va's Gamma Knife was the second in the U.S. and only the fifth in the world.

'Fatally flawed' legal analysis will not stand
Legal scholars advising the Alliance for Taxpayer Access quickly dismissed the faulty analysis made by the American Physiological Society's outside counsel suggesting the National Institutes of Health's public access plan will infringe copyright claims of grantees and publishers. [The claims were included in the APS comments filed with the NIH this week.]

Hopkins Institute for Global Tobacco Control receives elite recognition from PAHO/WHO
The Johns Hopkins Bloomberg School of Public Health Institute for Global Tobacco Control received the honor of being named a PAHO/WHO tobacco control surveillance and evaluation collaborating center. It is now among only three such centers in the United States.

Space sentinels track desertification on Mediterranean shores
The severe droughts and forest fires of recent years underline Mediterranean Europe's continuing vulnerability to desertification - 300 000 square kilometres of territory are currently affected, threatening the livelihoods of 16.5 million Europeans. A new satellite-based service is set to provide a continuous monitoring of regions most at risk.

Chernobyl disaster caused cancer cases in Sweden
Chernobyl disaster caused cancer cases in SwedenStudy of development of cancer in seven Swedish counties establishes connection A statistically determined correlation between radioactive fallout from the Chernobyl accident and an increase in the number of cases of cancer in the exposed areas in Sweden is reported in a study by scientists at Link.ping University, .rebro University, and the County Council of V.sternorrland County.

Good news about vitamin E
Don't toss out those vitamin E tablets just yet. Despite recent reports that show an association between high-dose vitamin E supplements and a higher overall risk of dying, about 40 percent of diabetic patients can REDUCE their risk of heart attacks and of dying by using the same vitamin.

New protein structure may aid in design of therapeutics for autoimmune disease
Scientists have determined the crystal structure of a protein kinase C (PKC) isozyme, in this case the novel PKC family member PKC theta (PKCΘ). This structure should prove extremely useful in the rational design of small molecule inhibitors of PKCΘ, which has been implicated in T-cell mediated disease processes including inflammation and autoimmunity.

Down Syndrome protein reduces tumor growth
Scientists have found that overexpression of a protein called Down Syndrome Critical Region 1 (DSCR-1) blocks the formation of new blood vessels and thus reduces tumor growth. Therapeutics based on this finding may potentially lead to new cancer treatments.

Data suggest ADDERALL XR . significantly improved simulated driving in young adults with ADHD
The Washington Neuropsychological Institute today announced that preliminary data suggested that ADDERALL XR (R) significantly improved simulated driving performance in young adults aged 19 to 25 with attention-deficit/hyperactivity disorder (ADHD) for up to 12 hours after taking the medication, as compared with placebo. In addition, ADDERALL XR significantly improved ADHD symptom control.

Capsules may be effective in treating bipolar disorder
University of North Carolina at Chapel Hill researchers have announced a formulation of three-beaded extended-release carbamazepine capsules (ERC-CBZ) was effective, safe and tolerable in the treatment of people with bipolar I disorder and showed no clinically significant weight gain or changes in blood glucose between treatment groups. The results are from two of the first phase 3 trials to use an extended-release form of carbamazepine capsules manufactured by Shire Pharmaceuticals.

Three-year health study of teenage girls is underway at Trenton Central High School
A novel program that measures the effect of intervention on the synergistic relationship between exercise, nutrition, cardiovascular health and self-esteem in adolescent girls is the foundation of a new three-year health study called Teen Esteem that has been introduced at Trenton Central High School by the Women's Heart Foundation.

New protein 'stop sign' alters blood vessel growth
In experiments with mice, a research team led by Johns Hopkins scientists has discovered an unusual protein pair that stops blood vessels' growth in the developing back. Results of the studies, published today in the express online edition of Science, are of special interest to researchers trying to prevent blood flow that nourishes tumors or exploit the signals vessels emit during growth to help regrow damaged nerves.

Ovarian cancer does have early warning signs, Mayo Clinic and Olmsted Medical Center find
Results from an Olmsted Medical Center and Mayo Clinic study analyzing symptoms recorded in the medical records of ovarian cancer patients suggest ovarian cancer, long considered asymptomatic until late-stage cancer develops, does in fact have early symptoms, including urinary incontinence and abdominal pain.

Were zoo workers infected with cancer-causing animal virus?
Evidence of exposure to a monkey virus possibly related to cancer has been found in the blood of North American zoo workers, according to a study in the December 15 issue of The Journal of Infectious Diseases, now available online. The virus, a polyomavirus known as simian virus 40 (SV40), has long been a subject of public health concern, in part because it has been shown to cause cancer in laboratory animals, and some investigators have reported SV40 DNA in human tumors.

Proposed addiction treatment successful, safe in second small trial
A second, small clinical trial of a proposed addiction treatment led by investigators at NYU School of Medicine and the U.S. Department of Energy's Brookhaven National Laboratory has produced favorable results in the treatment of long-term addiction to methamphetamine and/or cocaine, with no visual side effects in any of the 30 patients enrolled.

Prialt receives positive CHMP recommendation for intrathecal treatment of severe chronic pain
Elan Corporation, plc today announced that PRIALT (ziconotide) has received a positive recommendation from the European Committee for Medicinal Products for Human Use (CHMP), the human medicines scientific body of the European Medicines Agency. The CHMP has recommend that Prialt be indicated for the treatment of severe, chronic pain in patients who require intrathecal (IT) analgesia.

Gene expression profiling aids in ovarian cancer prognosis
The identification of a gene expression profile using microarray technology may help clinicians better determine the prognosis of patients with advanced stage ovarian cancer and may eventually help provide targeted therapies for this hard-to-treat disease, according to a study led by investigators at Beth Israel Deaconess Medical Center (BIDMC).

Ubiquitination in real-time: A world first at the Universit. de Montr.al
Universit. de Montr.al researchers succeeded in demonstrating that the ubiquitination process of a given protein can be monitored dynamically, in real time, on living cells.

'Plague and Fire' a tale of public health, imperialism, race relations, catastrophe
A new book analyzing the effects of scientific uncertainty on public policy during one of the worst public health debacles in America has been released by Oxford University Press. "Plague and Fire: Battling Black Death and the 1900 Burning of Honolulu's Chinatown" is by University of Oregon Professor of History James Mohr, an authority on medical jurisprudence.

Pain relief could be easy with a simple injection
A recent study, published in the journal Pain Practice, identified situations in which injections of local anesthetic would be the best treatment for pain and reduce unnecessary risk and procedural costs.

Study emphasizes importance of women in cardiac research
A recent trial, published in the Journal of Cardiovascular Electrophysiology, shows that women with abnormal heart rhythms benefit from implantable cardioverter defibrillators (ICDs) as much as men, stressing the importance of including females in future research.

Ventricular regulation may be key to preventing heart failure
A four-week study conducted on animals revealed that regulating ventricular rates and heart structure in models with irregular heart rhythms can inhibit chronic heart failure (CHF).

University of South Florida designated Center of Excellence by Huntington's Disease Society
The University of South Florida has been designated a regional Center of Excellence by the Huntington's Disease Society of America -- making it the only such HDSA Center for patients and their families in Florida.

Social supports lessen effects of maltreatment on children vulnerable to depression
Maltreated children who are genetically pre-disposed to depression can be spared lifelong emotional problems if the necessary social supports are made available to them.

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