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Eurekalert Medical and Health News: 02-24-2005

Fox Chase Cancer Center scientists identify immune-system mutation
In a study published in Nature, Fox Chase Cancer Center scientists have identified a new immune-system mutation that changes T-cell development from helper to killer cells. The spontaneous mutation was discovered in a strain of Fox Chase laboratory mice--a potentially useful new research tool for studying the development of immune response.

2005 ASM biodefense research meeting
The American Society for Microbiology (ASM) will host its 2005 Biodefense Research Meeting from March 20-23, 2005 at the Baltimore Marriott Waterfront Hotel in Baltimore, Maryland.

Kids with chronic illness face difficult transition to adult care
Technology and treatments have allowed a new wave of patients to survive until adulthood, further challenging the health-care system.

Penn study will compare heart failure management technologies
Researchers at the Hospital of the University of Pennsylvania (HUP) have been awarded a $1.5 million dollar grant from the Agency for Health Care Research and Quality and the National Institutes of Health to study disease management technologies in patients with heart failure, and patients with both heart failure and diabetes. The principal investigator for the two-site trial is Lee Goldberg, MD, MPH, Assistant Professor of Medicine and Medical Director of the Heart-Lung Transplant Program.

NASA awards $9.8 million NSCOR grant to UT Southwestern to study effects of space radiation exposure
UT Southwestern Medical Center has won a highly competitive, $9.8 million NASA Specialized Center of Research (NSCOR) grant that will allow researchers to study the effects of radiation on astronauts and minimize possible health risks caused by future space travel.

New radio-frequency technique for knee injuries
The application of a new technique for injuries of the cruciate ligament in the knee, involving the use of bipolar radio-frequency plus heat, has proved to be 90% effective in cases and shortens the recovery time of the patient. This project has received the National Prize for Research into Sports Medicine, awarded annually by the University of Oviedo.

Inpatient smoking cessation counseling is associated with early differences in mortality
In-hospital smoking cessation counseling following heart attacks is associated with better short-term survival. Counseling smokers to quit reduced their chances of dying in the first 30 days, 60 days and up to 1 year after their attacks.

Researchers model brain's electrical storm during a seizure
University of California researchers have created a mathematical model describing the electrical storm raging during a brain seizure. The new model, which was compared to data from a real seizure, may eventually help neurologists better understand and treat epilepsy. Their results are scheduled to be published in the March 22 print issue of the Journal of the Royal Society of London Interface.

OHSU scientists develop MRI approach to improve breast cancer detection
Researchers at Oregon Health & Science University's Advanced Imaging Research Center (AIRC) are developing a new imaging method that may provide a clearer diagnosis of breast cancer. The technique involves a new method for interpreting information gathered through magnetic resonance imaging. The technique involves recognizing that certain properties of MRI signals can change during the examination, much like the changing of a camera's shutter speed. This principle, when correctly applied to MRI imaging, can provide more accurate information for diagnosis.

Cartilage repair techniques shown to restore patient mobility and reduce pain
Two separate new studies presented at American Academy of Orthopedic Surgeon's (AAOS) annual meeting provide objective scientific evidence that the two most commonly performed cartilage repair techniques are effective at restoring patient mobility and reducing pain.

Sexual banter in workplace may have its benefits
A little sexual banter in the workplace isn't necessarily a bad thing. According to a news study sexualized encounters in some work situations actually can contribute to building camaraderie in a workforce.

Schepens scientists regenerate optic nerve for the first time
For the first time, scientists have regenerated a damaged optic nerve -- from the eye to the brain. This achievement, which occurred in laboratory mice and is described in the March 1, 2005 issue of the Journal of Cell Science, holds great promise for victims of diseases that destroy the optic nerve, and for sufferers of central nervous system injuries. "For us, this is a dream becoming reality," says Dr. Dong Feng Chen, lead author of the study.

Recent breakthroughs in common adult leukemia highlighted in New England Journal of Medicine
When the most common adult leukemia in the US was last reviewed by the New England Journal of Medicine in 1995, it was seen through the eyes of decades-old theories. The journal recently invited three of the world's foremost experts on chronic lymphocytic leukemia (CLL) to write an authoritative update covering the transformation in the scientific community's knowledge of CLL that has occurred over the past decade. The review appears in the February 24 issue.

CK2 protein sustains colon cancer cells by sabotaging ability to commit suicide
A protein called CK2 plays a deadly role in colorectal carcinoma by blocking the ability of these tumors to activate a natural self-destruct mechanism that would clear this cancer from the body. This finding, by researchers at St. Jude Children's Research Hospital, is currently published in the online edition of Oncogene.

Protein that promotes survival of stem cells might be key to poor leukemia prognosis
The complex and life-sustaining series of steps by which hematopoietic stem cells (HSC) give rise to all of the body's red and white blood cells and platelets has now been discovered to depend in large part on a single protein called Mcl-1. This finding, from an investigator at St. Jude Children's Research Hospital, is published in the February 18 issue of Science.

A safer route to school makes children more likely to walk and bike, study shows
A state program designed to make children's routes to school safer may actually be encouraging kids to walk or bike to school more often -- something that's good for their health.

Tiny particles could solve billion-dollar problem
New research from Rice University's Center for Biological and Environmental Nanotechnology finds that nanoparticles of gold and palladium are the most effective catalysts yet identified for remediation of one of the nation's most pervasive and troublesome groundwater pollutants, trichloroethene or TCE. The research, conducted by engineers at Rice and the Georgia Institute of Technology, will appear next month in the journal Environmental Science and Technology, a publication of the American Chemical Society.

TGen and Kronos initiate Alzheimer's disease study
Researchers at the Translational Genomics Research Institute (TGen) and Kronos Science Laboratories, an affiliate of Phoenix-based Kronos Optimal Health Company, have initiated a study with unprecedented power to identify genes that are involved in the development of Alzheimer's disease, the most common form of disabling memory and thinking problems in older persons.

Plant derivative attacks the roots of leukemia
A daisy-like plant known as Feverfew or Bachelor's Button, found in gardens across North America, is the source of an agent that kills human leukemia stem cells like no other single therapy, scientists have discovered.

Newly-discovered class of genes determines - and restricts - stem cell fate
Research on adult stem cells found in the skin hints at a new class of genes, according to a study from investigators at the University of Pennsylvania School of Medicine. These genes - dubbed pangenes - can both govern a stem cell's fate and put a hold on future differentiation until the time is right. Understanding the molecular control of these genes has implications for therapies that involve tissue regeneration.

Genome of deadly amoeba shows surprising complexity, evidence of lateral gene transfer
The genome sequence of the parasitic amoeba Entamoeba histolytica, a leading cause of severe diarrheal disease in developing countries, includes an unexpectedly complex repertoire of sensory genes as well as a variety of bacterial-like genes that contribute to the organism's unique biology. The report presents the first genome-wide study of an amoeba. An estimated 50 million people a year are infected by the parasite, which causes as many as 100,000 deaths annually.

Elusive HIV shape change revealed; Key clue to how virus infects cells
Structural biologists at Children's Hospital Boston and Harvard Medical School have shown how a key part of the human immunodeficiency virus (HIV) changes shape, triggering other changes that allow the AIDS virus to enter and infect cells. Their findings, published in the Feb. 24 issue of the journal Nature, offer clues that will help guide vaccine and treatment approaches.

Columbia study finds hemophilia therapy dramatically improves outcomes for bleeding stroke
A new multi-center, international study led by Columbia University Medical Center researchers at NewYork-Presbyterian Hospital/Columbia shows that recombinant activated factor VII (rFVIIa) has the potential to be a significant advance in treating bleeding stroke (acute intracerebral hemorrhage or ICH). Published in the New England Journal of Medicine (Feb. 24 issue), the study found a reduction in hematoma growth (bleeding in the brain), decreased mortality, and improvement in neurological and clinical outcomes in patients treated with rFVIIa compared to placebo.

Study identifies mechanism of resistance to targeted therapy in lung cancer patients
A new study led by investigators at Beth Israel Deaconess Medical Center (BIDMC) identifies a second mutation in a gene associated with non-small-cell lung cancer (NSCLC), a discovery that helps to explain why NSCLC tumors become resistant to treatment with the cancer therapy gefitinib (Iressa).

Latest findings on genetic blood disorder 'Cooley's Anemia'
The latest advances in understanding and treating Cooley's Anemia, an inherited life-threatening blood disorder, is the focus of an international conference on March 17-19 in Orlando, Florida. The event is sponsored by the Academy and the Cooley.s Anemia Foundation.

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