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Eurekalert Medical and Health News: 02-14-2005

COX-2 product offers good and bad news in 'test tube' strokes
Laboratory studies at Johns Hopkins have revealed that certain products of the enzymes COX-1 and COX-2 can both protect and damage the brain. The findings, published in the February 2005 issue of the Journal of Neurochemistry, offer tantalizing clues to why drugs like Vioxx and Celebrex, which block COX-2, can ease arthritis but potentially harm the heart and brain.

ESMO scientific & educational conference
A unique educational conference designed to offer updates on state-of-the-art oncology for the major tumor types as well as special interactive sessions for young medical oncologists.

Bacteria collection sheds light on urinary tract infections
Food of animal origin, contaminated with E.coli, can lead to urinary tract infections in women, according to a team of bacteriologists.

Breast cancer treatment reduces risk of heart disease
Women with breast cancer treated with the anti-estrogen drug tamoxifen are at significantly less risk of having a heart attack or symptoms of heart stress such as angina, according to a new study.

Women with thyroid problem have lower risk of breast cancer
According to a new study, women suffering from a common thyroid problem called hypothyroidism, a condition in which the thyroid gland fails to produce enough thyroid hormone, are less likely to develop breast cancer than women with normal thyroid function.

Hypothyroidism associated with reduced breast cancer risk
Researchers at The University of Texas M. D. Anderson Cancer Center have found that women with a common thyroid gland disorder appear to have a reduced chance of developing invasive breast cancer, according to a study published in the March 15 issue of Cancer, out online Feb. 14.

Stem cell therapy for spinal injury
Researchers at Karolinska Institutet have shown how the transplantation of stem cells improves recovery from spinal injury. However, a painful condition can also develop, which can be prevented if the stem cells are supplemented with a certain gene that controls their maturing process. The results are important for planning of stem cell therapy trials on patients with spinal injury.

Internet dating much more successful than thought
Internet dating is proving a much more successful way to find long-term romance and friendship for thousands of people than was previously thought, new research shows.

Morbidly obese pay nearly twice as much for health care
University of Cincinnati researchers have found that the morbidly obese have a substantially higher economic burden when it comes to health care costs.

UCLA scientists transform HIV into cancer-seeking missile
Camouflaging an impotent AIDS virus in new clothes enables it to hunt down metastasized cancer cells in living mice, reports a UCLA AIDS Institute study in the Feb. 13 online edition of Nature Medicine. The scientists added the protein that makes fireflies glow to the virus in order to track its journey from the bloodstream to new tumors in the animals' lungs.

Prior caesarean delivery not linked to increased risk of stillbirth
Women with a history of caesarean section deliveries do not have a higher risk of a subsequent stillbirth, according to researchers at Yale School of Medicine and Columbia University.

Amgen's decision to block reinstatement of GDNF is faulted by a leading Parkinson's advocacy group
The Amgen announcement to forgo the offer of reinstatement of GDNF to patients who were involved in recent clinical trials of the treatment is deeply disappointing to the Parkinson's Disease Foundation, to the Parkinson's community, and to the participating patients. This decision denies the patients and their doctors the opportunity to continue with a potentially useful, albeit yet unproven, treatment, and it denies us all the opportunity to gather more scientific data about the long-term effects of GDNF.

Preparing for the inevitable: New book for nurses guides patient care during a disaster
Driven by the Sept. 11 terror attacks and what they observed in Israel, two Saint Louis University nursing professors wrote a textbook on what nurses should do during a disaster.

Gladstone Institutes rank high in the scientist survey of best places for postdocs
The J. David Gladstone Institutes, a group of UCSF-affiliated medical research institutes, is among the top 15 institutional work environments for life sciences postdoctoral fellows, according to The Scientist's annual "Best Places to Work for Postdocs" survey, set to be published in the February 14 issue.

Ingestion of afterbirth appears to promote maternal behavior in mammals
A behavioral neuroscientist at the University at Buffalo holds that the ingestion of afterbirth by a mother, a feature of pregnancy in nearly all non-human mammals, not only relieves postpartum pain, but optimizes the onset of maternal behavior by mediating the activity of specific opioid activity circuits in the brain.

Research focusing on why estrogenic hormones produce differing results
New research is shedding light on why estrogenic hormones produce unintended results in women, giving hope to the idea that new drugs might reach their targets and work more effectively. Ultimately it could mean that postmenopausal women would know that hormone-replacement therapy would have only its intended result.

Penn joins major NCI research initiative to advance breast cancer therapies
The University of Pennsylvania School of Medicine was recently selected to become a member of the National Cancer Institute's Mouse Models of Human Cancers Consortium Penn is one of four MMHCC sites at which breast-cancer models are being developed and studied, out of 24 total sites. The group will employ a broad array of state-of-the-art cellular and molecular imaging techniques to analyze a series of novel, genetically engineered mouse models of breast cancer.

Rat brain's executive hub quells alarm center if stress is controllable
When it deems a stressor controllable, an executive hub in the front of the brain quells an alarm center deep in the brainstem, preventing the adverse behavioral and physiological effects of uncontrollable stress. Rats exposed to uncontrollable stress develop learned helplessness, a syndrome similar to depression. "It's as if the prefrontal cortex says: 'Cool it, brainstem! We have control over this and there is no need to get so excited'," quipped Steven Maier, Ph.D.

Sprinklers shown effective in slowing dorm fires
An automatic sprinkler system significantly increases a person's chances of surviving a dormitory fire, according to a report issued recently by the National Institute of Standards and Technology (NIST).Three NIST experiments,* supported by a U.S. Fire Administration (USFA) initiative for fire safety in college housing, compared the hazards of fires in smoke detector-equipped dormitories with and without fire sprinklers in the room of fire origin.

Dialogue & personal example work best for parents in drug talks with teens
Parents can more effectively advise teens about alcohol and drug use if, first, they try dialogue instead of lecture and, second, they set an everyday example, rather than give the one-time drug sermon, according to a Penn State researcher.

Falling in love in three minutes or less
It seems that the heart wants what the heart wants - and it can figure it out fairly quickly, according to evolutionary psychologists at the University of Pennsylvania. The researchers studied data from 10,526 anonymous participants of speed dating parties and found rare behavioral data on how people genuinely act in dating situations. The data show that, when people meet face-to-face, things like smoking preferences and bank accounts don't seem to figure into the complexities of attraction.

A startling diary reveals the onset of autism
A meticulous diary kept by a mother of twins has revealed indicators of autistic behaviour in children as young as six months of age. The findings are published today in Neurocase. Mel Rutherford, assistant professor of psychology at McMaster University, says the diary provides a rare and unprecedented opportunity to observe the early development of autism.

Transport system smuggles medicines into brain
Dutch researcher Corine Visser investigated a new way of transporting medicines into the brain. Her approach made use of an iron transport system located on the blood-brain barrier. The smaller the medicine, the more easily it penetrates the brain.

Emory researchers find more evidence for children's growth spurts, pain
The existence of growth spurts and growing pains in children may be perpetually evident to parents, but their cause has lacked scientific explanation. A new study now sheds some light on this childhood phenomena.

International trial of two microbicides begins
A large, multisite trial designed to examine the safety and preliminary effectiveness of two candidate topical microbicides to prevent HIV infection has opened to volunteer enrollment. The trial, sponsored by the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health, represents a partnership among various research institutions in Africa and the United States.

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