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Eurekalert Medical and Health News: 02-03-2005

Effective cancer treatments follow the clock
Oncologists have long thought that cancer treatments tend to be more effective at certain times of day. But they have been unable to turn this knowledge into practice. Now, researchers have discovered a molecular mechanism that explains why sensitivity to anti-cancer drugs changes with the clock. The findings could lead to new drug treatments that may be more effective because they harness the power and precision of the body's internal clock.

Special imaging study shows failing hearts are 'energy starved'
Using magnetic resonance spectroscopy (MRS) for the first time to examine energy production biochemistry in a beating human heart, Johns Hopkins researchers have found substantial energy deficits in failing hearts.

Older people get the big picture faster, and they are less inhibited
The long-held belief that older people perform slower and worse than younger people has been proven wrong. In a study published today in Neuron, psychologists from McMaster University discovered that the ageing process actually improves certain abilities: Older people appear to be better and faster at grasping the big picture than their younger counterparts.

Cell research signals cancer hope
Scientists have moved a step closer to understanding what happens when cells receive a faulty signal that is known to be a cause of cancer.

Poverty in Northern Ireland
Senior social scientists and policy-makers meet in Belfast tomorrow (Friday, February 4) to explore how far the government is succeeding in abolishing child poverty, reducing social exclusion, and improving equal opportunities in Northern Ireland.

Bacterial spread all down to chance: Some strains 'just the lucky ones'
Scientists have discovered that factors such as human immunity and drug resistance are less important to the success of bacterial spread than previously thought.

Rheumatoid arthritis patients at higher risk for unrecognized heart disease and cardiac sudden death
People with rheumatoid arthritis not only have a higher risk of coronary heart disease than those in the general population, but they have more silent, unrecognized heart attacks and sudden cardiac deaths.

States find alternate routes to health coverage
"State of the States: Finding Alternate Routes," released today. This annual report, produced by The Robert Wood Johnson Foundation's State Coverage Initiatives program (SCI), tells the story of state health coverage activities from the previous year.

Rheumatoid arthritis linked to excess risk of congestive heart failure
The authors' findings indicate rheumatoid arthritis as a significant risk factor for congestive heart failure - independent of established risk factors for heart attack and a history of atherosclerosis.

Optimal treatment of carpal tunnel syndrome
Results of a recent clinical trial by a team of researchers in Madrid suggest that local steroid injection is just as effective as surgery for the long-term symptomatic relief of carpal tunnel syndrome - for a year, at least - and actually more effective over the short term.

Rheumatoid arthritis patients have double the risk of heart failure
Mayo Clinic researchers have found that rheumatoid arthritis patients have twice the risk of heart failure, or a weakening of the heart's ability to pump blood, as those without rheumatoid arthritis.

Opportunity missed: TIA patients receive less aggressive attention than those with stroke
Transient ischemic attack (TIA) patients receive less aggressive diagnostic testing, treatment and education compared to stroke patients, which is a missed opportunity to prevent permanent disability or death, researchers reported at the American Stroke Association's International Stroke Conference 2005.

Migraine-sparked vision loss may increase stroke risk in women; Migraine
Women who experience vision loss as a symptom of migraine have a 70 percent increase in risk of stroke compared to women who don't have migraines, researchers reported today at the American Stroke Association's International Stroke Conference 2005.

Smoking hurts wealth as well as health, study suggests
Maybe packs of cigarettes should come with a new warning: "Smoking is hazardous to your wealth." A new study suggests that typical non-smokers' net worth is roughly 50 percent higher than that of light smokers and about twice the level of that of heavy smokers.

New neurons born in adult rat cortex
Scientists have found newly born neurons that communicate via the chemical messenger GABA in adult rat cortex, seat of higher order "executive" functions, and in the striatum, site of habits and reward learning. The new cortex neurons appear to arise from previously unknown precursor cells native to the area. The discovery adds to the scientific debate over adult neurogenesis, which has potential implications for understanding a variety of brain disorders.

Mayo Clinic researchers create 'obedient virus'; First step to use measles virus against cancer
An international team of Mayo Clinic-led researchers is first to devise a system that consistently converts the measles virus into a therapeutic killer that hunts down and destroys cancer cells -- and cancer cells only. Their research findings appear in the current issue of Nature Biotechnology http://www.nature.com/nbt/.

NASA research to aid federal invasive species council efforts
NASA recently accepted an invitation to join the National Invasive Species Council (NISC). NASA, in a research capacity, will assist 12 other federal agencies' efforts to combat invasive species across the country.

IDSA applauds Senate leadership for introduction of S. 3
The Infectious Diseases Society of America (IDSA) today applauded the Senate Republican leadership for putting biopreparedness at the top of its health care agenda. IDSA pledged to work with members of Congress on both sides of the aisle to enact comprehensive legislation to spur the development of new medicines, vaccines, and diagnostics for infectious diseases, particularly new antibiotics that target drug-resistant infections.

New study in JAMA details trends in diagnosis, treatment of brain tumors
A two year study involving over 560 patients with the newly-diagnosed malignant brain tumors shows that patterns of care are varied and there is a need for new, detailed clinical guidelines for management of brain tumors. The study is published in the Feb. 2, 2005 issue of the Journal of the American Medical Association (JAMA), available at www.jama.ama-assn.org.

Inflammatory cells highly promising target in NF 1
Indiana University School of Medicine researchers are identifying drugs that can disrupt the function of mast cells and their proteins in ways that they believe will starve NF tumors.

Think fast: Reaction time and IQ may predict long life
Studies have shown that people with lower IQs tend to die at younger ages than those with higher IQs. New research suggests that reaction time may be a better indicator of long life.

NJIT professor receives NSF CAREER award for emergency response research
David Mendonca, Ph.D., an assistant professor of information systems at New Jersey Institute of Technology (NJIT) who has worked to improve the way society responds to disasters, has received a National Science Foundation (NSF) CAREER award - the foundation's most prestigious award for new faculty members.

NJIT expert recommends 16 easy, affordable ways to make homes safer for people with disabilities
Environmental psychologist Richard Olsen, PhD, a research professor at New Jersey Institute of Technology (NJIT), has developed 16 easy and affordable ways people can make their homes safer and more comfortable.

Research using mouse models reveals a novel key player in the initiation of colon cancer
Klaus Kaestner from the University of Pennsylvania School of Medicine has headed a study that identifies another molecular player influencing the initiation of colon cancers. This study will be published in the February 1 issue of the journal Genes and Development.

Suffering from fatigue, abdominal discomfort or bloody diarrhea?
People living with fatigue, abdominal discomfort and bloody diarrhea caused by the chronic inflammation of ulcerative colitis may no longer need to undergo frequent and uncomfortable endoscopies, a new study shows.

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