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Eurekalert Medical and Health News: 12-23-2004

Ocean colour satellites guide research ship through South Pacific's watery desert
There is a desert in the heart of the South Pacific. Surrounding Easter Island is the purest and bluest seawater on Earth, almost empty of the microscopic phytoplankton at the base of the marine food web. French vessel L'Atalante recently completed a research cruise through this region, its day-to-day route guided by ocean colour satellites.

Sudden death from stress linked to wonky signals in the brain
Sudden cardiac death from emotional stress may be triggered by uneven signals from the brain to the heart, according to a study by University College London (UCL) scientists published in the January issue of Brain.

Patient protection laws don't favor health providers
Despite critics who say patients' bills of rights laws are actually designed to protect health care providers, new research published in the current issue of the American Journal of Medicine found just the opposite.

Healthy mix of GI tract microbes are key to preventing allergies and asthma
If you want to avoid allergies or asthma, scientists at the University of Michigan Medical School suggest you start paying more attention to what's in your gut.

FDA approves Enablex for treatment of overactive bladder
East Hanover, December 22, 2004 - Novartis Pharmaceuticals Corporation today announced that the U.S. Food and Drug Administration (FDA) has approved Enablex. (darifenacin) extended-release tablets (7.5mg and 15mg) for the treatment of overactive bladder (OAB) with symptoms of urge urinary incontinence, urgency and frequency. Enablex, a once-daily medication, is expected to launch in the U.S. in early 2005.

Cells don festive holiday colors
The latest holiday gifts being offered to the scientific community this season by scientists in the laboratory of Howard Hughes Medical Institute investigator Roger Y. Tsien come in a dazzling variety of hues -- cherry, strawberry, tangerine, tomato, orange, banana and honeydew. The color spectrum would make Pantone proud. No, Tsien's group is not giving out fruit baskets; the names describe vibrant new varieties of fluorescent protein that the researchers have created to tag cells and observe a range of cellular processes.

Immune system contributes to evolution of a new fluorescent protein
Fascinated by the efficient way the human immune system generates a rapid response to create a near-infinite variety of antibodies, researchers have "hijacked" that machinery and used it to evolve a new type of fluorescent protein. The researchers say their technique is widely applicable, and should prove useful in mutating genes faster to produce proteins with useful new properties.

HydroGlobe acquired by Graver Technologies
HydroGlobe, a Technogenesis environmental technology company incubated at Stevens Institute of Technology, which produces patented products for the removal of heavy metals - including lead and arsenic - from water, has been acquired by Graver Technologies, a leading manufacturer of filtration and separation products.

Inexpensive, mass-produced genes at core of synthetic biology advances at UH
Devices the size of pagers now have greater capabilities than computers that once occupied an entire room. Similar advances are being made in synthetic biology at the University of Houston, now allowing researchers to mass produce and inexpensively program the chemical synthesis of entire genes on a single microchip. The findings of Professor Xiaolian Gao are appearing in the current issue of Nature in the paper "Accurate multiplex gene synthesis from programmable DNA microchips."

MSI reveals invention for detection and precise quantification of molecules
Researchers at The Molecular Sciences Institute revealed means for sensitive detection and precise quantification of arbitrarily designated molecules. The work is published in the current issue of Nature Methods.

ASTRO patient education campaign wins award
The American Society for Therapeutic Radiology and Oncology in Fairfax, Va., has won the Award of Excellence in the 2005 Associations Advance America awards program, a national competition sponsored by the American Society for Association Executives. ASTRO received the award for its public awareness campaign to help cancer patients and their families better understand their treatment options. The campaign is now in the running to receive a Summit Award, ASAE's top honor for association programs.

McMaster researchers develop test for rare bleeding disorder
Researchers at McMaster University have developed the first assessment tool of its kind for evaluating risks faced by Canadians suffering from a rare and often fatal bleeding disorder.Their detailed bleeding questionnaire helps discriminate between patients - often in the same family - affected by a puzzling and rare condition known as Quebec Platelet Disorder (QPD) and those who are not.

Small band of nurses plays key role keeping germ threats at bay
Flu. Smallpox. Anthrax. Whooping cough. The words represent a veritable murderers' row of infectious agents whose death toll runs in the millions. Between them and us stand a few small groups of nurses at select institutions around the country who protect the population from such scourges.

'Casanova' field crickets - live fast, die young
Well-fed male field crickets die young because they spend too much time courting members of the opposite sex, according to research by Australian scientists in the latest edition of Nature.The results reveal how male crickets (Teleogryllus commodus) fed on a high protein diet engaged in more "sexual calling" and died sooner than males reared on a low protein diet. The well-fed males also died earlier than well-fed female crickets (females don't "call" to males).

Chromosome 16 publication fulfills DOE's human genome commitment
The US Department of Energy Joint Genome Institute (JGI), culminating a 16-year effort, has completed its share of the Human Genome Project with the publication of the DNA sequence and analysis of chromosome 16 in the Dec. 23 issue of Nature.

'Jumping gene' helps explain immune system's abilities
A team led by Johns Hopkins scientists has found the first clear evidence that the process behind the human immune system's remarkable ability to recognize and respond to a million different proteins might have originated from a family of genes whose only apparent function is to jump around in genetic material.

Breast reconstruction with implants after mastectomy doesn't hurt survival chances
Breast implants after mastectomy to treat breast cancer do not reduce the long-term survival of patients, reveals the first study on the long-term effects of breast implants, published today in Breast Cancer Research.

New test possible aid to overcoming barriers to colon cancer screening
Study published in the December 23 issue of New England Journal of Medicine reports that a non-invasive test for DNA mutations present in stool has an encouraging rate of detecting colorectal cancer compared to the standard non-invasive method -- fecal occult (hidden) blood stool testing, although neither approached the detection rate of colonoscopy.

Women seeking treatment for even minimal 'male-type' hair growth need endocrine evaluation
Premenopausal women who seek help for excessive hair growth, even if it is not significant enough to meet the clinical definition of hirsutism, need to be evaluated for endocrine and reproductive system abnormalities. In a study of 188 women, researchers found that more than half of patients with only minimal unwanted hair growth in male-type patterns had excessive amounts of "male" hormones. While this symptom is often considered merely cosmetic, the underlying causes and long-term consequences may be serious.

Discovery of key protein's shape could lead to improved bacterial pneumonia vaccine
Scientists at St. Jude Children's Research Hospital have discovered that the shape of a protein on the surface of pneumonia bacteria helps these germs invade the human bloodstream. This finding, published Dec. 16 online by the EMBO Journal, could help scientists develop a vaccine that is significantly more effective at protecting children against the disease.

Mayo Clinic researchers find PDAs okay with pacemakers
With the dynamic evolution of wireless technology, Mayo Clinic researchers have been concerned about the potential effects of electromagnetic interference on heart pacemakers and implantable cardioverter-defibrillators. In the current issue of Mayo Clinic Proceedings, researchers report they did not detect interference from personal digital assistants (PDAs).

Tracing the life cycle of a manmade disease
In the December issue of Clinical Orthopedics and Related Research, orthpaedic surgeon William Harris, MD, DSc, of Massachusetts General Hospital tells a remarkable story of how a new disease was inadvertently caused by successful medical treatment, ultimately understood, and eventually defeated by scientific innovation.

Detoxification in nation's jails falls short
.Very few jails in the United States continue methadone treatments for opiate-dependent inmates, and half fail to follow standard methadone detoxification protocols, according to a national survey by the University of Rochester Medical Center.

Race may be factor in doctor-patient communication style
Doctors are less likely to actively engage their black patients in conversation when compared to the conversations they had with their white patients, according to a new study of primary care visits conducted by researchers at the Johns Hopkins Bloomberg School of Public Health and School of Medicine.

Blocking cell suicide switch fails to stop prion damage in mouse brains
Researchers knew that prions, the misfolded proteins that cause mad cow disease and other brain disorders, were killing off a class of important brain cells in a transgenic mouse model. But when they found a way to rescue those cells, they were astonished to discover the mice still became sick.

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