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Eurekalert Medical and Health News: 04-03-2006

COX-2 inhibitors significantly reduce risk of cancer
Results from a new, five-year study show that regular use of popular prescription pain relievers may reduce the risk of breast cancer by up to 71 percent and may offer similar benefit in the prevention of prostate, colon and lung cancers.

ROZEREM. (ramelteon) showed significant reduction in time to fall asleep with no evidence
Results of a sub-analysis from a Phase III clinical study showed that ROZEREM(ramelteon) significantly reduced time to fall asleep in adults with chronic insomnia and showed no evidence of rebound insomnia or withdrawal effects. The results were presented today at the 2006 Annual Meeting of the American Academy of Neurology.

Researchers working on a better method of detecting ovarian cancer
Promising research conducted at the University of South Florida and H. Lee Moffitt Cancer Center on a specific protein in the urine may lead to a more sensitive screening test in the future for women with ovarian cancer.

Discovery at the Feinstein suggests new treatment approach for inflammatory conditions
Scientists at The Feinstein Institute for Medical Research in Manhasset, NY, have made a discovery that may change the way inflammatory conditions are treated. The study, by Valentin Pavlov, PhD, Kevin Tracey, MD, and colleagues, was published in the March 28 print issue of Proceedings of the National Academy of Sciences, and suggests that use of drugs in the class of centrally acting cholinergic agents may be an effective approach for managing inflammation.

Abdominal fat linked to higher death rate in men, new study shows
A new study by Queen's University researchers shows for the first time that visceral fat in the abdomen is directly associated with a higher risk of mortality in men.

New study suggests schools should add nondairy beverages to the lunch menu
Offering soymilk to elementary school students boosts the number of children who select a calcium-rich beverage in the lunch line and reduces the amount of saturated fat consumed from calcium-rich beverages, according to a study in April's Journal of the American Dietetic Association.

Weekly religious attendance nearly as effective as statins and exercise in extending life
In a study comparing the associations between faith and health, a University of Pittsburgh Medical Center (UPMC) physician has shown that the improvements in life expectancy of those who attend religious services on a weekly basis are comparable to those who participate in regular physical exercise and those who take statin-type medications. The study author cautions that while religious attendance seems beneficial, it is not a substitute for regular medical care.

Mom's nutrition during pregnancy related to child's behavior at age three
Children born to teenage mothers who were iron deficient early in their pregnancies were less active at age 3 than the children of iron sufficient moms, a Penn State study has shown.

TV viewing during lunch affects preschool children's intake
In a recent Penn State laboratory study, preschool children who usually eat meals at home while watching TV ate one-third more lunch when they were shown a cartoon video during lunchtime versus when they ate lunch without TV.

Relative risks of cirrhosis from non-alcoholic steatohepatitis
According to a new study, cirrhosis related to non-alcoholic steatohepatitis (NASH) is associated with fewer complications and a lower mortality compared to cirrhosis from hepatitis C, despite NASH patients' greater risk of dying from cardiovascular events.

Intrahepatic cholestasis during pregnancy associated with later liver disease
A retrospective case-control study of 21,008 women in Finland has found that those with intrahepatic cholestasis of pregnancy (ICP), an itchy skin condition when bile gets backed up in the liver, are significantly more likely to suffer other liver diseases later in life.

Genomatix technology facilitates de novo identification of new renal disease associated genes
Previously unknown molecules and regulatory pathways in human glomerular diseases have been identified by a joint effort of the Medizinische Poliklinik, Munich, the University of Bristol's Children's Renal Unit, the German Cancer Research Center, sanofi-aventis, and Genomatix Software GmbH.

Takeda submits new drug application for extended-release type 2 diabetes medication, ACTOplus met.
Takeda Global Research & Development Center (TGR&D) today announced that the company has submitted a New Drug Application (NDA) for an extended-release version of the combination medication ACTOplus met (pioglitazone HCl and metformin HCl) to the United States Food and Drug Administration (FDA) for the treatment of type 2 diabetes. This new formulation (ACTOplus met XR) would allow for once-daily dosing, while ACTOplus met (immediate release) is already available, being marketed by Takeda Pharmaceuticals North America, Inc.

An affordable future for eye tracking in sight
An ambitious five-year project will attempt to make eye-tracking technologies more affordable for people with disabilities and extend the potential use of the devices to enable users to live more independently.

New uses for endoscopy
Braquitherapy guided by ecoendoscopy has enabled a therapeutic approach to injuries, hitherto inaccessible by other means. Another novelty with the endoscopic approach is as an alternative to surgery for obesity.

80% of vasectomy patients didn't complete all-clear semen tests
80% of 436 vasectomy patients didn't complete the two semen tests needed to see if they were in the clear and a quarter didn't attend ANY tests at all. Yet a quarter of the men who did attend their first, eight-week test were still producing sperm and some still needed further testing at 12 weeks.

Teens turn to pot after parental bust-ups
Splitting parents who shack up with new partners can unwittingly push their children towards cannabis use.

Differences in pregnancy risks and outcomes among immigrant groups to the US
Since the number of people of Hispanic and Asian origins has been increasing in the United States, it is important for healthcare workers to assess the risk factors associated with pregnancy outcomes in these ethnic groups. A study in the March issue of The Journal of Pediatrics evaluates the genetic, biologic, and social factors that may affect the fetal growth of babies born to U.S. and foreign-born Mexican and Asian-Indian mothers.

One big biology question solved
An Australian research team has solved one of biology's most fundamental questions - why males produce sperm and females produce eggs.

In stretching, pain doesn't equal gain; but if NO isn't producing, stretching won't help
Cumulative muscle injury may contribute to the loss of muscle mass as we grow old. So protecting muscles at all times is a good thing, and understanding how stretching increases resistance to injury will really help to do this. Nitric oxide seems necessary for protection, but a potential positive role for neutrophils strikes many as odd.

Targeted therapies showing great promise against colorectal cancer
Results from a Phase III study of a new drug show promise for patients with colorectal cancer that has spread to other parts of the body, according to a study presented today during the 97th Annual Meeting of the American Association for Cancer Research.

Studies confirm celecoxib may help prevent colorectal cancer in high risk patients
During the past year, the study of the potential use of COX-2 (cyclooxygenase-2) inhibitors to prevent colorectal and breast cancer has come under intense scrutiny. Recent research questioned the safety of these medicines as pain relievers, which was the initial indication, as well as for chemoprevention of cancer. Now, the latest data show that COX-2 inhibitors are highly effective in preventing pre-malignant tumors of the colon, and therefore may be useful in preventing colorectal cancer among high-risk patients.

Researchers seek alternative for leukemia patients resistant to standard therapies
A study led by researchers from the Howard Hughes Medical Institute has found that dasatinib provides significant benefit in chronic myeloid leukemia (CML) patients resistant to Gleevec. (imatinib), according to a study presented today during the 97th Annual Meeting of the American Association for Cancer Research.

Racial disparities in cancer not as simple as black and white
African-Americans are more likely to develop cancer and to die from this disease than any other racial or ethnic group in the US population.

Research shows adults and teens who eat beans weigh less
A study unveiled today gives new meaning to the word beanpole: The findings show that people who eat beans weigh less than those who don't.Presented at the Experimental Biology conference, April 1-5 in San Francisco, the study found that adults who eat beans weigh 6.6 pounds less - yet eat 199 more daily calories - than adults who don't eat beans.

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